![]() Through this, they found that chromosomal abnormalities in the inner cell mass were rare, even if the trophectoderm analysis suggested low- to medium-grade mosaicism. They additionally examined 91 unselected human blastocysts donated for research, collecting multiple trophectoderm samples and an inner cell mass sample for 75 of the embryos for sequencing. ![]() Biopsies of the samples' trophectoderms underwent next-generation sequencing-based analysis, which uncovered a diploid-aneuploid mosaicism incidence of 18.7 percent. To examine the incidence of chromosomal mosaicism, the researchers first analyzed a historical dataset of 6,766 embryos. "We believe the clinical data generated from this trial will resolve some of the major concerns that arise during pre-implantation genetic testing and will be of fundamental importance for helping many infertile patients make more informed reproductive decisions," first author Antonio Capalbo from Igenomix Italy said in a statement. In a blinded clinical study, they further found no difference in live-birth or miscarriage rates between euploid and low- or medium-grade mosaic embryos, as they reported Thursday in the American Journal of Human Genetics. Researchers from the reproductive genomics firm Igenomix and elsewhere examined the distribution of aneuploid chromosomes in pre-implantation embryos and trophectoderm biopsies, finding that when mosaicism levels were less than 50 percent, only a few aneuploidies affected other parts of the embryo. But some analyses have indicated that chromosomal mosaicism in embryos may sometimes be confined to a small number of cells that do not affect development. This finding could increase the number of in vitro fertilization embryos available for implantation.Ĭurrently, most embryos exhibiting aneuploidy are not selected for implantation during IVF, as aneuploidy is a common cause of pregnancy loss and congenital disorders. NEW YORK - Low or medium levels of mosaic aneuploidy among embryos does not affect their developmental potential or pregnancy outcomes, a new study has found.
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